Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy.
BACKGROUND Plasminogen activator inhibitor-1 (PAI-1) is increased in kidneys of humans and animals with diabetic nephropathy and is associated with extracellular matrix (ECM) accumulation. PAI-1 may promote ECM buildup by preventing plasmin and matrix metalloproteinase (MMP) activation. However, the importance and mechanism of PAI-1 action in the pathogenesis of diabetic nephropathy is unknown....
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ژورنال
عنوان ژورنال: Kidney International
سال: 2005
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2005.00207.x